| Letlalo la Tlhokomelo ea Letlalo Sejo Saense Series| Niacinamide (vithamine B3)

Niacinamide (Panacea lefatšeng la tlhokomelo ea letlalo)

"Niacinamide", e tsejoang hape e le vithamine B3 (VB3), ke mofuta o sebetsang oa bioloji oa niacin 'me o fumaneha haholo liphoofolong le limela tse fapaneng. Hape ke selelekela sa bohlokoa sa li-cofactors tsa NADH (nicotinamide adenine dinucleotide) le NADPH (nicotinamide adenine dinucleotide phosphate). Hammoho le NADH le NADPH tse fokotsehileng, li sebetsa joalo ka li-coenzymes ka liketso tse fetang 40 tsa biochemical mme hape li sebetsa joalo ka li-antioxidants.

Haholo-holo e sebelisoa ho thibela le ho phekola pellagra, stomatitis, glossitis le mafu a mang a amanang le ona.

karolo ea bohlokoa ka ho fetisisa
1.Letlalo le kganyang le ho sweufala

Nicotinamide e ka theola ho tsamaisoa ha melanosome ho tloha melanocyte ho ea ho keratinocyte ntle le ho thibela ts'ebetso ea tyrosinase kapa ho ata ha lisele, ka hona e ama letlalo la letlalo. E ka boela ea kena-kenana le tšebelisano pakeng tsa keratinocyte le melanocyte. Mecha ea lipontšo tsa lisele lipakeng tsa lisele e fokotsa tlhahiso ea melanin. Ka lehlakoreng le leng, nicotinamide e ka sebetsa ho melanin e seng e hlahisitsoe mme ea fokotsa phetiso ea eona liseleng tse kaholimo.

Pono e 'ngoe ke hore nicotinamide e boetse e na le ts'ebetso ea anti-glycation, e ka hlapollang' mala o mosehla oa protheine ka mor'a glycation, e tla thusa ho ntlafatsa 'mala oa letlalo oa lifahleho tsa mebala ea meroho esita le "basali ba sefahleho se mosehla".
Eketsa kutloisiso

Ha niacinamide e sebelisoa e le motsoako o soeufatsang, ka har'a motsoako oa 2% ho isa ho 5%, ho ipakile e sebetsa ho alafong chloasma le hyperpigmentation e bakoang ke mahlaseli a ultraviolet.

2.Khahlanong le botsofali, ho ntlafatsa mela e metle (anti-free radicals)

Niacinamide e ka hlasimolla collagen synthesis (e eketsa lebelo le bongata ba collagen synthesis), ea eketsa ho tsitsisa ha letlalo, 'me ea fokotsa ponahalo ea mela e metle le makukuno. E boetse e na le thepa ea antioxidant e fokotsang li-radicals tsa mahala le ho liehisa ts'ebetso ea ho tsofala ha letlalo.
Eketsa kutloisiso

Liphuputso li bontšitse hore ho sebelisa nicotinamide (5% content) ho ka fokotsa masoebi, erythema, mosehla le matheba letlalong la sefahleho le tsofalang.

3.Lokisa letlalomosebetsi oa mokoallo
Tokiso ea Niacinamide ea ts'ebetso ea tšitiso ea letlalo e bonahala haholo ka likarolo tse peli:

① Khothalletsa ho qaptjoa ha ceramide letlalong;

②Potlakisa phapang ea lisele tsa keratin;
Tšebeliso e ka holimo ea nicotinamide e ka eketsa maemo a mafura a mafura a mahala le li-ceramide letlalong, ea susumetsa microcirculation ka har'a dermis, le ho thibela tahlehelo ea mongobo oa letlalo.

E boetse e eketsa protheine synthesis (e kang keratin), e eketsa maemo a intracellular NADPH (nicotinamide adenine dinucleotide phosphate), 'me e potlakisa phapang ea keratinocyte.
Eketsa kutloisiso

Bokhoni ba ho ntlafatsa ts'ebetso ea tšitiso ea letlalo e boletsoeng ka holimo e bolela hore niacinamide e na le matla a mongobo. Lithuto tse nyane li bonts'a hore 2% niacinamide e sebetsa hantle ho feta petroleum jelly (petroleum jelly) ho fokotsa tahlehelo ea metsi a letlalo le ho eketsa metsi.

Molemo ka ho fetisisa motsoako oa metsoako
1. Motsoako oa ho tlosa bosoeu le matheba: niacinamide +retinol A
2. Motsoako o tebileng oa mongobo:asiti ea hyaluronic+ squalane